Needing a higher dose for the same effect? It's not your or your metabolisms fault.

Recent data is incredibly interesting that even though women tend to respond with greater weight loss with GLP1s especially Tirzepatide, there may be an Estrogen AND genetic component to how you respond individually. Large study in Nature showed that gene receptor expression causes some people to have either larger side effects and/or higher response to GLP1s. Then theres the data that GLP1 receptors INCREASE in expression in response to high estrogen states. WHAT?! That means that you may respond more in different parts of your cycle AND if you are in a low estrogen state (perimenopause or postmenopause) you may need higher levels of GLP1 to get the same response!

Anyone seeing this? I definitely have in my clinical practice.